Beth Israel Deaconess Medical Center – Boston, Hospital
… MRI and other behavioral measures to assess the effects of Melodic Intonation Therapy in facilitating Language Recovery. His areas of expertise include …
Director, Neuroimaging Laboratory
Co-Director of Comprehensive Stroke Center
Staff Neurologist, BIDMC
Associate Professor of Neurology, Harvard Medical School
Dr. Gottfried Schlaug, currently Director of Neuroimaging at the Beth Israel Deaconess Medical Center and Assistant Professor of Neurology at Harvard Medical School, received an M.D. and a Ph.D. in Neurology and Neuroscience from the University of Cologne (Germany). He completed residencies in Neurology both at the University of Duesseldorf (Germany) and at Beth Israel Deaconess Medical Center – Harvard Medical School (Boston). He then completed a fellowship in Stroke/MRI at the Beth Israel Deaconess Medical Center.
Dr. Schlaug’s research interests involve:
- pathophysiology of acute human stroke: using MR perfusion and diffusion imaging to base treatment decisions on risks and benefit assessments;
- structural-functional relationships within cortical auditory and motor areas: using musicians as a model to study cerebral correlates of musical abilities;
- Functional and structural MR imaging to to study cerebral adaptations as well as cognitive enhancements to skill acquisition;
- Functional MRI and TMS to study correlates of sensorimotor recovery from stroke;
- Functional MRI and other behavioral measures to assess the effects of Melodic Intonation Therapy in facilitating Language Recovery.
His areas of expertise include clinical neurology, stroke diagnosis and therapy, diffusion and perfusion imaging, stroke recovery, and functional neuroimaging.
His hobbies include classical music as a keyboard performer and mountain hiking.
· Gaab N, Schlaug G. The Effect of musicianship on pitch memory in performance matched groups. Neuroreport 2003;14:2291-2295
· Gaser C, Schlaug G. Brain structures differ between musicians and non-musicians. J Neuroscience 2003;23:9240-9245.
· Kobayashi M, Hutchinson S, Theoret H, Schlaug G, Pascual-Leone A. Repetitive TMS of the motor cortex improves ipsilateral sequential simple finger movements. Neurology 2004;62:91-99.
· Linfante I, Hirsch HA, Selim M, Schlaug G, Caplan LR, Reddy AS. Safety of latest-generation self-expanding stents in patients with NASCET-ineligible severe symptomatic extracranial internal carotid artery stenosis. Arch Neurol 2004;61:39-43.
· Northoff G, Heinzel A, Bempohl F, Niese R, Pfennig A, Pascual-Leone A, Schlaug G. Reciprocal modulation and attenuation in the prefrontal cortex: An fMRI study on emotional-cognitive interaction. Human Brain Mapping 2004;21:202-212.
· Gaab N, Paetzold M, Becker M, Walker MP, Schlaug G. The influence of sleep on auditory learning – a behavioral study. Neuroreport 2004;15:731-734.
· Hamilton R, Pascual-Leone A, Schlaug G. Absolute Pitch in Blind Musicians. Neuroreport 2004;15:803-806.
· Lueders E, Gaser C, Schlaug G. A voxel-based approach to gray-matter asymmetries. Neuroimage 2004; 22:656-664.
· Norton A, Winner E, Cronin K, Overy K, Lee DJ, Schlaug G. Young children beginning instrumental music training: are there pre-existing anatomical brain, cognitive, or motoric markers? Brain and Behavior 2005, in press
· Overy K, Norton A, Cronin K, Gaab N, Alsop D, Winner E, Schlaug G (2004). Differential lateralization for melody versus rhythm is already present in young children. Neuroreport 15:1723-1726.
· Koelsch S, Fritz T, Schulze K, Alsop D, Schlaug G. Adults and children processing music: an fMRI study. Neuroimage 2005;25:1068-1076.
· Selim M, Savitz S, Gomes J, Linfante I, Caplan L, Finley A, Schlaug G. Effect of pre-stroke use of angiotensin-converting enzyme inhibitors on ischemic stroke severity. BMC Neurol 2005;Jun 10:5:10 A
· lsop, DC, Makovetskaya E, Kumar S, Selim M, Schlaug G. Markedly Reduced Apparent Blood Volume on Bolus Contrast MRI as a Predictor of Hemorrhage Following Thrombolytic Therapy for Acute Ischemic Stroke. Stroke 2005;36:746-750.
· Walker, M, Stickgold R, Alsop D, Gaab N, Schlaug G. Sleep-dependent motor memory plasticity in the human brain. Neuroscience 2005;133:911-917.
· Savitz I, Schlaug G, Caplan L, Selim M. Gender differences in response to thrombolysis, Stroke 2005,;36:1447-1451
· Hutchinson S, Lee LHL, Gaab N, Schlaug G. Cerebellar volume: gender and musicianship effects. Cerebral Cortex 2003, 13:943-949.
· Gaab N, Keenan J, Schlaug G. The effects of gender on the neural substrates of musical functions. J Cogn Neurosci 2003; 15:810-820.
· Gaab N, Gaser C, Zaehle T, Chen Y, Schlaug G. Functional anatomy of pitch memory – a fMRI study with sparse temporal sampling. NeuroImage 2003, 19:1417-1426.
· Kobayashi M, Hutchinson S, Theoret H, Schlaug G, Pascual-Leone A. Repetitive TMS of the motor cortex improves ipsilateral sequential simple finger movements. Neurology 2004;23:9240-9245 .
· Kobayashi M, Hutchinson S, Schlaug G, Pascual-Leone A. Ipsilateral motor cortex activation on functional magnetic resonance imaging during unilateral hand movements is related to interhemispheric interactions. Neuroimage 2003, in press
· Mottaghy FM, Gangitano M, Horkan C, Chen Y, Pascual-Leone A, Schlaug G. Repetitive TMS temporarily alters brain diffusion. Neurology. 2003 May 13;60(9):1539-41.
· Sanger TD, Pascual-Leone A, Tarsy D, Schlaug G. fMRI evidence of sensory receptive fields spanning multiple fingers in Writer’s cramp. Movement Disorders, 2003 May 13;60(9):1539-41.
· Lee DJ, Chen Y, Schlaug G. Corpus callosum: musician and gender effects. Neuroreport. 2003 Feb 10;14(2):205-9.
· Hutchinson S, Kobayashi M, Horkan CM, Pascual-Leone A, Alexander MP, Schlaug G. Age-related differences in movement representation. Neuroimage. 2002 Dec;17(4):1720-8.
· Linfante I, Llinas RH, Selim M, Chaves C, Kumar S, Parker RA, Caplan LR, Schlaug G. Clinical and vascular outcome in internal carotid artery versus middle cerebral artery occlusions after intravenous tissue plasminogen activator. Stroke. 2002 Aug;33(8):2066-71.
· Selim M, Fink JN, Kumar S, Caplan LR, Horkan C, Chen Y, Linfante I, Schlaug G. Predictors of hemorrhagic transformation after intravenous recombinant tissue plasminogen activator: prognostic value of the initial apparent diffusion coefficient and diffusion-weighted lesion volume. Stroke. 2002 Aug;33(8):2047-52.
· Selim M, Fink J, Linfante I, Kumar S, Schlaug G, Caplan LR. Diagnosis of cerebral venous thrombosis with echo-planar T2*-weighted magnetic resonance imaging. Arch Neurol. 2002 Jun;59(6):1021-6. Review.
· Fink JN, Selim MH, Kumar S, Silver B, Linfante I, Caplan LR, Schlaug G. Is the association of National Institutes of Health Stroke Scale scores and acute magnetic resonance imaging stroke volume equal for patients with right- and left-hemisphere ischemic stroke? Stroke. 2002 Apr;33(4):954-8.
· Fink JN, Kumar S, Horkan C, Linfante I, Selim MH, Caplan LR, Schlaug G. The stroke patient who woke up: clinical and radiological features, including diffusion and perfusion MRI. Stroke. 2002 Apr;33(4):988-93.
· Selim M, Kumar S, Fink J, Schlaug G, Caplan LR, Linfante I. Seizure at stroke onset: should it be an absolute contraindication to thrombolysis? Cerebrovasc Dis. 2002;14(1):54-7.
· Keenan JP, Halpern AR, Thangaraj V, Chen C, Edelman RR, Schlaug G. Absolute pitch and planum temporale. Neuroimage 2001 Dec;14(6):1402-8.
· Linfante I, Llinas RH, Schlaug G, Chaves C, Warach S, Caplan LR. Diffusion-weighted imaging and National Institutes of Health Stroke Scale in the acute phase of posterior-circulation stroke. Arch Neurol. 2001 Apr;58(4):621-8.
· Schlaug G. The Musician Brain: Evidence for functional and structural adaptation. Ann NY Acad Sci 2001;930: 281-299.
· Baird AE, Lovblad KO, Dashe JF, Connor A, Burzynski C, Schlaug G, Straroselskaya I, Edelman RR, Warach S. Clinical correlations of diffusion and perfusion lesion volumes in acute ischemic stroke. Cerebrovasc Dis. 2000 Nov-Dec;10(6):441-8.
· Chaves CJ, Silver B, Schlaug G, Dashe J, Caplan LR, Warach S. Diffusion- and perfusion-weighted MRI patterns in borderzone infarcts. Stroke. 2000 May;31(5):1090-6
· Baird AE, Lovblad KO, Schlaug G, Edelman RR, Warach S. Multiple acute stroke syndrome: marker of embolic disease? Neurology. 2000 Feb 8;54(3):674-8.
· Schlaug G, Benfield A, Baird AE, Siewert B, Lovblad KO, Parker RA, Edelman RR, Warach S. The ischemic penumbra: defining brain tissue at risk for infarction using diffusion and perfusion MRI. Neurology 1999;53:1528-1537.
· Jakob PM, Schlaug G, Griswold M, Lovblad KO, Thomas R, Ives JR, Matheson JK, Edelman RR. Functional burst imaging. Magn Reson Med. 1998 Oct;40(4):614-21
· Lovblad KO, Laubach HJ, Baird AE, Curtin F, Schlaug G, Edelman RR, Warach S. Clinical experience with diffusion-weighted MR in patients with acute stroke. AJNR Am J Neuroradiol. 1998 Jun-Jul;19(6):1061-6.
· Lovblad KO, Jakob PM, Chen Q, Baird AE, Schlaug G, Warach S, Edelman RR.Turbo spin-echo diffusion-weighted MR of ischemic stroke. AJNR Am J Neuroradiol. 1998 Feb;19(2):201-8; discussion 209.
· Schlaug G, Siewert B, Benfield A, Edelman RR, Warach S. Time course of the apparent diffusion coefficient (ADC) abnormality in human stroke. Neurology 1997;49:113-119.
Lovblad KO, Baird AE, Schlaug G, Benfield A, Siewert B, Voetsch B, Connor A, Burzynski C, Edelman RR, Warach S. Ischemic lesion volumes in acute stroke by diffusion-weighted magnetic resonance imaging correlate with clinical outcome. Ann Neurol. 1997 Aug;42(2):164-70.